B-Tensor: Brain Connectome Tensor Factorization for Alzheimer's Disease

AD is the highly severe part of dementia spectrum and impairs cognitive abilities individuals, bringing economic, societal psychological burdens beyond diseased. A promising approach in research analysis structural functional brain connectomes, i.e., sNETs fNETs, respectively. We propose to use tensor representation (B-tensor) uni-modal multi-modal connectomes define a low-dimensional space via factorization. show on cohort 47 subjects, spanning dementia, that diagnosis with an accuracy 77% 100% achievable 5D connectome using different constructions fashion. further factorization improves results suggesting complementary information structure function. neurological assessment connectivity patterns identified largely agrees prior knowledge, yet also suggests new associations may play role disease progress.